GUCA2B

Across TCGA patient cohorts, GUCA2B mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCA2B-associated genes across cancer lineages are MTCYBP36, LINC01441, and MTND5P17. Each is linked with GUCA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCA2B-to-partner and partner-to-GUCA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP36 grouped by GUCA2B-low versus GUCA2B-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA2B→partner) and Y-score (partner→GUCA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MTCYBP36 →	+0.187	+6.257	<.001	.001	3	2
READ	LINC01441 →	+0.035	+5.421	<.001	.005	3	1
READ	MTND5P17 →	+0.055	+5.925	<.001	.002	3	1
READ	NDUFA4P2 →	+0.293	+5.219	<.001	.006	3	1
READ	OR13K1P →	+0.085	+5.219	<.001	.006	3	1
READ	S100A11P5 →	+0.264	+5.219	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

MTCYBP36 by GUCA2B expression — READ

Explore this box plot interactively →