GUCA2B

Across TCGA pan-cancer cohorts, GUCA2B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of GUCA2B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GUCA2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GUCA2B is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

KIRC, COAD, and READ are the cancer types where GUCA2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GUCA2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+3.053	<.001	12	view →
COAD	Male	IV	−6.541	<.001	11	view →
READ	Female	All	−6.824	<.001	7	view →
LUAD	Female	III,IV	−0.781	<.001	4	view →
LUSC	Female	All	−0.665	<.001	4	view →
KICH	All	All	−0.194	.003	4	view →
HNSC	Male	III,IV	+0.191	.010	3	view →
CHOL	All	II,III,IV	−2.125	.013	2	view →
STAD	All	All	−1.187	.041	2	view →
UCEC	All	All	+0.070	.039	2	view →
ESCA	Female	All	−3.739	.039	1	view →
KIRP	All	All	+0.499	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

GUCA2B–KIRC

Open the KIRC breakdown →