Across TCGA patient cohorts, GUCA2A mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GUCA2A-associated genes across cancer lineages are USP12, LINC00445, and LINC02559. Each is linked with GUCA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both GUCA2A-to-partner and partner-to-GUCA2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GUCA2A→partner) and Y-score (partner→GUCA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	USP12 →	+0.685	+3.225	.003	.009	3	1
SKCM	LINC00445 →	+0.055	+4.292	<.001	<.001	3	1
SKCM	LINC02559 →	+0.094	+4.039	<.001	.009	3	1
SKCM	NMBR-AS1 →	+0.116	+3.776	<.001	.003	3	1
SKCM	SPIN2P1 →	+0.268	+3.632	<.001	.008	3	1
SKCM	SNORD13P1 →	+0.764	+3.044	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Exploration

GUCA2A survival (RNA) · tumor vs normal (RNA) · all GUCA2A data types