GTSE1-DT

Across TCGA pan-cancer cohorts, GTSE1-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GTSE1-DT’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GTSE1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types GTSE1-DT is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where GTSE1-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTSE1-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.087	<.001	11	view →
KIRC	Male	II,III,IV	−0.972	<.001	11	view →
LIHC	All	III,IV	+0.207	<.001	9	view →
HNSC	Male	All	+0.419	<.001	7	view →
LUSC	Female	All	+1.052	<.001	6	view →
KIRP	All	All	−0.593	<.001	6	view →
BLCA	All	All	+0.508	.003	6	view →
CHOL	Male	All	+0.875	<.001	3	view →
COAD	Female	IV	−0.575	.001	1	view →
STAD	Male	IV	−0.135	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GTSE1-DT–THCA

Open the THCA breakdown →