GTF2I

Across TCGA patient cohorts, GTF2I protein abundance is significantly associated with the RNA expression of many other genes, with 19,378 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GTF2I-associated genes across cancer lineages are PMPCB, CPSF4, and BUD23. Each is linked with GTF2I in more than 8 cancer types. Because this analysis shows association rather than direction, both GTF2I-to-partner and partner-to-GTF2I results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GTF2I versus PMPCB in HNSC, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2I→partner) and Y-score (partner→GTF2I) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PMPCB →	+0.575	+0.447	.001	<.001	3	9
UCEC	CPSF4 →	+1.029	+0.321	<.001	<.001	3	9
HNSC	BUD23 →	+0.542	+0.557	<.001	<.001	3	9
HNSC	DNAJC2 →	+0.625	+0.359	<.001	<.001	3	8
BRCA	ACTR3B →	+0.830	+0.420	<.001	<.001	3	8
UCEC	MCM7 →	+1.443	+0.372	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,378 associations by consensus.

GTF2I vs PMPCB — HNSC

Explore this scatter interactively →