GTF2H5

Across TCGA cell cohorts, GTF2H5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,139 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GTF2H5-associated GO terms across cancer lineages are Negative regulation of ubiquitin protein ligase activity, Protein-DNA complex assembly, and Regulation of protein exit from endoplasmic reticulum. Each is linked with GTF2H5 in more than 10 cancer types. Because this analysis shows association rather than direction, both GTF2H5-to-partner and partner-to-GTF2H5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of ubiquitin protein ligase activity grouped by GTF2H5-low versus GTF2H5-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GTF2H5→partner) and Y-score (partner→GTF2H5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of ubiquitin protein ligase activity →	+0.183	+0.963	.003	.001	2	11
BREAST	Protein-DNA complex assembly →	+0.052	+0.802	.001	.002	3	8
SKIN	Regulation of protein exit from endoplasmic reticulum →	+0.108	+0.801	<.001	<.001	3	7
SOFT_TISSUE	Golgi vesicle transport →	+0.038	+0.572	.002	.001	3	7
SOFT_TISSUE	Threonyl-tRNA aminoacylation →	-0.113	-0.659	<.001	.002	3	7
LUNG_NSCLC_LUAD	Regulation of protein ADP-ribosylation →	+0.068	+0.413	.005	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,139 associations by consensus.

Negative regulation of ubiquitin protein ligase activity by GTF2H5 expression — LUNG_NSCLC_LUSC

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