GTF2H5

Across TCGA pan-cancer cohorts, GTF2H5 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GTF2H5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where GTF2H5 RNA is repressed in tumor relative to normal tissue. In most cancer types GTF2H5 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, LIHC, and HNSC are the cancer types where GTF2H5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GTF2H5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.567	<.001	11	view →
LIHC	Female	II,III,IV	+0.552	<.001	8	view →
HNSC	All	III,IV	+0.286	.005	6	view →
KIRC	Male	All	−0.243	<.001	6	view →
CHOL	All	All	+0.927	<.001	4	view →
COAD	All	All	+0.285	.006	4	view →
THCA	Male	II,III,IV	−0.338	.012	3	view →
BLCA	Male	III,IV	−0.629	.016	2	view →
LUSC	All	All	+0.215	.019	2	view →
LUAD	All	All	+0.164	.020	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GTF2H5–KICH

Open the KICH breakdown →