GTF2H5

Across TCGA pan-cancer cohorts, GTF2H5 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GTF2H5 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GTF2H5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GTF2H5 expression acts as an unfavorable survival marker, although some lineages such as THCA and LGG show a favorable association.

HNSC, KICH, and THCA are the cancer types where GTF2H5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.518	0.655	<.001	108	view →
KICH	OS	Median	All	0.652	1.000	.001	80	view →
THCA	DFS	Median	All	0.910	0.752	<.001	65	view →
OV	DFS	Quartile	All	0.482	0.612	.018	28	view →
UVM	OS	Quartile	II,III,IV	0.470	0.865	.011	26	view →
UCS	DFS	Tertile	IV	0.440	0.942	.038	24	view →
KIRP	DFS	Quartile	All	0.835	0.956	.005	21	view →
MESO	OS	Median	All	0.431	0.667	.003	17	view →
LGG	DFS	Quartile	All	0.502	0.300	.011	17	view →
CESC	OS	Tertile	All	0.731	0.862	.014	16	view →
LIHC	OS	Median	III,IV	0.392	0.657	.001	15	view →
PRAD	OS	Tertile	All	0.924	0.774	.012	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GTF2H5–HNSC (DFS)

Open the HNSC breakdown →