Across TCGA cell cohorts, GSPT2 mutation is significantly associated with the RNA expression of many other genes, with 206 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GSPT2-associated genes across cancer lineages are SHOC2, FAM149A, and ALDH6A1. Each is linked with GSPT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSPT2-to-partner and partner-to-GSPT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT2→partner) and Y-score (partner→GSPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SHOC2 →	+0.540	+3.212	<.001	.006	3	1
LARGE_INTESTINE	FAM149A →	+1.491	+3.082	<.001	.007	3	1
LARGE_INTESTINE	ALDH6A1 →	+1.100	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ALKBH7 →	+0.528	+3.212	.001	.006	3	1
LARGE_INTESTINE	ZNF436 →	+0.767	+3.212	<.001	.006	3	1
LARGE_INTESTINE	GALR3 →	+0.087	+3.865	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 206 associations by consensus.

Exploration

GSPT2 survival (RNA) · tumor vs normal (RNA) · all GSPT2 data types