Across TCGA pan-cancer cohorts, GSPT2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GSPT2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where GSPT2 RNA is repressed in tumor relative to normal tissue. In most cancer types GSPT2 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, THCA, and KIRC are the cancer types where GSPT2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSPT2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.