Across TCGA cell cohorts, GSPT2 mutation is significantly associated with the mutation status of many other genes, with 3,905 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GSPT2-associated genes across cancer lineages are CDC5L, KCNA3, and TRIM9. Each is linked with GSPT2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GSPT2-to-partner and partner-to-GSPT2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT2→partner) and Y-score (partner→GSPT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CDC5L →	+5.392	+5.392	.004	.004	1	4
BLOOD_Leukemia	KCNA3 →	+5.894	+5.321	.002	.002	1	4
UPPER_AERODIGESTIVE_TRACT	TRIM9 →	+5.392	+5.392	.004	.004	1	4
LARGE_INTESTINE	AAK1 →	+4.217	+2.865	.007	.007	1	4
CNS	DOCK7 →	+4.459	+5.277	.005	.005	1	4
UPPER_AERODIGESTIVE_TRACT	TBX2 →	+5.392	+5.392	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,905 associations by consensus.

Exploration

GSPT2 survival (RNA) · tumor vs normal (RNA) · all GSPT2 data types