GSPT1

Across TCGA patient cohorts, GSPT1 mutation is significantly associated with the RNA expression of many other genes, with 150 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSPT1-associated genes across cancer lineages are RN7SL62P, RNY4P18, and PPIAP69. Each is linked with GSPT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GSPT1-to-partner and partner-to-GSPT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL62P grouped by GSPT1-low versus GSPT1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSPT1→partner) and Y-score (partner→GSPT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL62P →	+0.110	+4.812	<.001	.006	3	2
SKCM	RNY4P18 →	+0.377	+4.199	<.001	.009	3	2
SKCM	PPIAP69 →	+0.122	+4.328	<.001	.007	3	2
CESC	RNU1-62P →	+0.250	+4.539	<.001	.008	3	2
BRCA	H2AB2 →	+0.062	+7.473	<.001	.007	3	1
BRCA	MIR6842 →	+0.328	+4.646	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 150 associations by consensus.

RN7SL62P by GSPT1 expression — CESC

Explore this box plot interactively →