GSG1L

Across TCGA patient cohorts, GSG1L mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSG1L-associated genes across cancer lineages are p62 Lck ligand, Rictor_pT1135, and JNK_pT183_Y185. Each is linked with GSG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both GSG1L-to-partner and partner-to-GSG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by GSG1L-low versus GSG1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSG1L→partner) and Y-score (partner→GSG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.308	+1.807	.021	.027	3	2
UCEC	Rictor_pT1135 →	-0.095	-3.169	.024	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.146	-1.794	.035	.027	3	1
UCEC	LKB1 →	-0.090	-2.999	.040	.035	3	1
UCEC	Mre11 →	-0.078	-2.321	.028	.006	3	1
UCEC	PCNA →	+0.218	+2.459	.014	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

p62 Lck ligand by GSG1L expression — UCEC

Explore this box plot interactively →