GSG1L

Across TCGA pan-cancer cohorts, GSG1L RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GSG1L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GSG1L RNA is repressed in tumor relative to normal tissue. In most cancer types GSG1L is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where GSG1L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GSG1L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−0.168	<.001	12	view →
COAD	Male	II,III,IV	−0.303	<.001	10	view →
LUAD	All	III,IV	−0.298	<.001	9	view →
KIRP	All	III,IV	−0.133	<.001	7	view →
UCEC	All	All	−0.436	.003	6	view →
READ	All	II,III,IV	−0.329	.005	6	view →
STAD	All	II,III,IV	−0.193	<.001	6	view →
LUSC	Female	All	−0.361	<.001	5	view →
PRAD	All	All	−0.116	.003	2	view →
LIHC	All	II,III,IV	−0.012	.019	2	view →
HNSC	All	II,III,IV	−0.041	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GSG1L–KIRC

Open the KIRC breakdown →