GSG1L

Across TCGA pan-cancer cohorts, GSG1L RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GSG1L data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher GSG1L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GSG1L expression acts as an unfavorable survival marker, although some lineages such as LUAD and ACC show a favorable association.

UCEC, LUAD, and LGG are the cancer types where GSG1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.546	0.743	.007	84	view →
LUAD	DFS	Median	All	0.843	0.747	.001	74	view →
LGG	OS	Median	All	0.361	0.544	<.001	40	view →
SCLC	DFS	Tertile	IV	0.110	0.446	.010	36	view →
SKCM	OS	Tertile	All	0.190	0.509	<.001	24	view →
ACC	DFS	Median	IV	0.495	0.066	.001	20	view →
UCS	DFS	Tertile	II,III,IV	0.545	0.130	.006	18	view →
DLBC	DFS	Quartile	All	0.575	1.000	.016	15	view →
UVM	OS	Tertile	III,IV	0.782	1.000	.004	14	view →
BRCA	OS	Quartile	III,IV	0.913	0.748	.003	13	view →
COAD	OS	Quartile	IV	0.378	0.719	.010	12	view →
PCPG	DFS	Quartile	All	0.786	0.959	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GSG1L–UCEC (OS)

Open the UCEC breakdown →