GSC

Across TCGA patient cohorts, GSC mutation is significantly associated with the RNA expression of many other genes, with 1,012 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GSC-associated genes across cancer lineages are TMEM225, RNU4-58P, and RPL26P34. Each is linked with GSC in more than 1 cancer types. Because this analysis shows association rather than direction, both GSC-to-partner and partner-to-GSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM225 grouped by GSC-low versus GSC-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSC→partner) and Y-score (partner→GSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	2
SKCM	RNU4-58P →	+0.369	+5.970	<.001	.002	3	2
SKCM	RPL26P34 →	+0.088	+5.292	<.001	.006	3	2
SKCM	SOCS2P1 →	+0.177	+6.624	<.001	.001	3	2
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
READ	RNU6-1274P →	+0.547	+5.925	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,012 associations by consensus.

TMEM225 by GSC expression — READ

Explore this box plot interactively →