GSC

Across TCGA pan-cancer cohorts, GSC RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated GSC data layer compared with 3 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GSC RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GSC expression acts as an unfavorable survival marker, although some lineages such as COAD and SKCM show a favorable association.

ACC, KIRP, and CESC are the cancer types where GSC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.411	0.841	<.001	120	view →
KIRP	OS	Tertile	All	0.612	0.870	<.001	42	view →
CESC	DFS	Median	II,III,IV	0.575	0.812	.001	40	view →
LIHC	OS	Tertile	All	0.479	0.712	.002	36	view →
COAD	DFS	Quartile	III,IV	0.575	0.274	.003	28	view →
UCS	DFS	Tertile	IV	0.237	0.938	.024	24	view →
LGG	DFS	Tertile	All	0.355	0.463	.005	22	view →
HNSC	OS	Median	All	0.604	0.724	.005	20	view →
PRAD	DFS	Tertile	All	0.680	0.878	.002	16	view →
SKCM	DFS	Tertile	IV	0.629	0.041	.004	15	view →
THCA	OS	Quartile	III,IV	0.924	1.000	.018	14	view →
LUAD	DFS	Quartile	IV	0.196	0.594	.022	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GSC–ACC (OS)

Open the ACC breakdown →