GSC

Across TCGA cell cohorts, GSC mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GSC-associated genes across cancer lineages are C3orf85, PRSS54, and MAGEB4. Each is linked with GSC in more than 1 cancer types. Because this analysis shows association rather than direction, both GSC-to-partner and partner-to-GSC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C3orf85 grouped by GSC-low versus GSC-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GSC→partner) and Y-score (partner→GSC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C3orf85 →	+0.059	+5.539	<.001	.003	3	1
LARGE_INTESTINE	PRSS54 →	+0.058	+4.930	<.001	.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.017	+4.415	<.001	.007	3	1
LARGE_INTESTINE	RNASE8 →	+0.043	+4.930	<.001	.001	3	1
LARGE_INTESTINE	OR14I1 →	+0.014	+4.415	.001	.007	3	1
LARGE_INTESTINE	KRTAP10-5 →	+0.025	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

C3orf85 by GSC expression — BLOOD_Leukemia

Explore this box plot interactively →