GRWD1

Across TCGA cell cohorts, GRWD1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRWD1-associated genes across cancer lineages are AADACL2, MSMB, and PRSS54. Each is linked with GRWD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRWD1-to-partner and partner-to-GRWD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AADACL2 grouped by GRWD1-low versus GRWD1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRWD1→partner) and Y-score (partner→GRWD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	AADACL2 →	+0.015	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	MSMB →	+0.052	+4.523	.008	.004	3	1
LARGE_INTESTINE	PRSS54 →	+0.046	+3.930	<.001	.003	3	1
LARGE_INTESTINE	C14orf180 →	+0.126	+4.155	<.001	.003	3	1
SKIN	CT45A9 →	+1.370	+4.095	.001	.009	3	1
BLOOD_Leukemia	SPRR3 →	+0.041	+3.949	.004	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

AADACL2 by GRWD1 expression — BLOOD_Lymphoma

Explore this box plot interactively →