GRWD1

Across TCGA pan-cancer cohorts, GRWD1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of GRWD1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GRWD1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRWD1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LIHC, and HNSC are the cancer types where GRWD1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRWD1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.008	<.001	11	view →
LIHC	Female	II,III,IV	+1.045	<.001	9	view →
HNSC	Male	All	+0.798	<.001	9	view →
STAD	Male	II,III,IV	+1.200	<.001	8	view →
LUSC	Male	II,III,IV	+0.725	<.001	6	view →
KICH	All	All	−0.708	<.001	6	view →
BLCA	All	III,IV	+0.419	.010	6	view →
BRCA	All	All	+0.278	<.001	6	view →
CHOL	Male	All	+1.778	<.001	5	view →
KIRP	All	II,III,IV	+0.450	.002	5	view →
LUAD	All	III,IV	+0.438	.001	5	view →
KIRC	Female	All	+0.375	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

GRWD1–COAD

Open the COAD breakdown →