GRPEL2

Across TCGA patient cohorts, GRPEL2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRPEL2-associated genes across cancer lineages are MEK1, Tuberin, and BRCA2. Each is linked with GRPEL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRPEL2-to-partner and partner-to-GRPEL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GRPEL2-low versus GRPEL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRPEL2→partner) and Y-score (partner→GRPEL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.376	+3.000	.049	.036	3	1
UCEC	Tuberin →	+0.336	+3.321	.017	.010	3	1
UCEC	BRCA2 →	-0.161	-3.162	.020	.019	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MEK1 by GRPEL2 expression — UCEC

Explore this box plot interactively →