GRPEL2

Across TCGA pan-cancer cohorts, GRPEL2 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated GRPEL2 data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher GRPEL2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRPEL2 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

LIHC, KIRP, and UCEC are the cancer types where GRPEL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.463	0.620	<.001	111	view →
KIRP	DFS	Tertile	II,III,IV	0.253	0.667	.001	76	view →
UCEC	DFS	Median	All	0.781	0.891	<.001	70	view →
SCLC	OS	Median	All	0.427	0.719	<.001	62	view →
UVM	DFS	Tertile	III,IV	0.279	0.854	.004	52	view →
READ	DFS	Tertile	II,III,IV	0.758	0.387	.004	47	view →
STAD	OS	Quartile	II,III,IV	0.433	0.756	.002	43	view →
CESC	DFS	Quartile	III,IV	0.254	0.792	.002	38	view →
PAAD	OS	Tertile	II,III,IV	0.345	0.689	.001	31	view →
LGG	OS	Median	All	0.839	0.949	<.001	28	view →
KIRC	DFS	Quartile	All	0.874	0.756	.001	28	view →
OV	OS	Quartile	IV	0.765	0.442	.015	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GRPEL2–LIHC (DFS)

Open the LIHC breakdown →