GRPEL1

Across TCGA patient cohorts, GRPEL1 mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRPEL1-associated genes across cancer lineages are SNRPGP17, MIR8082, and MIR6747. Each is linked with GRPEL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRPEL1-to-partner and partner-to-GRPEL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPGP17 grouped by GRPEL1-low versus GRPEL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRPEL1→partner) and Y-score (partner→GRPEL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNRPGP17 →	+0.270	+2.686	.008	.002	3	1
UCEC	MIR8082 →	+0.500	+3.298	<.001	<.001	3	1
UCEC	MIR6747 →	+0.944	+2.428	<.001	.006	3	1
COAD	RNU6-379P →	+0.732	+4.717	<.001	.003	3	1
COAD	RNU6-1250P →	+0.507	+4.693	<.001	.007	3	1
COAD	VN1R90P →	+0.204	+4.993	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

SNRPGP17 by GRPEL1 expression — UCEC

Explore this box plot interactively →