GRK3

Across TCGA patient cohorts, GRK3 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,689 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GRK3-associated proteins across cancer lineages are RTN1, HDGFL3, and RPS5. Each is linked with GRK3 in more than 6 cancer types. Because this analysis shows association rather than direction, both GRK3-to-partner and partner-to-GRK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRK3 versus RTN1 in OV, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK3→partner) and Y-score (partner→GRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RTN1 →	+0.644	+0.632	<.001	<.001	3	7
UCEC	HDGFL3 →	+0.666	+0.377	.001	.009	3	5
COAD	RPS5 →	-0.211	-0.499	.002	<.001	3	5
LSCC	S100A16 →	-0.812	-0.516	<.001	.001	3	5
COAD	KCTD12 →	+0.453	+0.606	<.001	<.001	3	5
GBM	EVL →	+0.522	+0.558	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,689 associations by consensus.

GRK3 vs RTN1 — OV

Explore this scatter interactively →