GRK3

Across TCGA patient cohorts, GRK3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,299 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GRK3-associated genes across cancer lineages are CCDC69, IL12RB1, and CRYBB1. Each is linked with GRK3 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRK3-to-partner and partner-to-GRK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRK3 versus CCDC69 in HNSC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK3→partner) and Y-score (partner→GRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CCDC69 →	+1.188	+0.495	.002	.001	3	5
HNSC	IL12RB1 →	+1.214	+0.491	.001	.001	3	5
GBM	CRYBB1 →	+0.570	+0.277	<.001	<.001	3	4
HNSC	NCF4 →	+1.672	+0.541	<.001	<.001	3	4
GBM	PPP1R16B →	+1.462	+0.361	<.001	<.001	3	4
HNSC	RASAL3 →	+0.748	+0.330	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,299 associations by consensus.

GRK3 vs CCDC69 — HNSC

Explore this scatter interactively →