GRK3

Across TCGA cell cohorts, GRK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,984 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRK3-associated GO terms across cancer lineages are Positive regulation of DNA repair, Symbiont-mediated disruption of host cellular anatomical structure, and Symbiont-mediated disruption of host anatomical structure. Each is linked with GRK3 in more than 11 cancer types. Because this analysis shows association rather than direction, both GRK3-to-partner and partner-to-GRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by GRK3-low versus GRK3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK3→partner) and Y-score (partner→GRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of DNA repair →	+0.055	+1.423	<.001	<.001	2	12
KIDNEY	Symbiont-mediated disruption of host cellular anatomical structure →	+0.126	+0.741	<.001	<.001	3	11
KIDNEY	Symbiont-mediated disruption of host anatomical structure →	+0.126	+0.741	<.001	<.001	3	11
BLOOD_Leukemia	Microtubule polymerization →	+0.093	+1.416	<.001	<.001	3	10
OESOPHAGUS	Positive regulation of DNA recombination →	+0.075	+0.758	<.001	.003	3	10
SOFT_TISSUE	Microtubule nucleation →	+0.101	+1.420	.002	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,984 associations by consensus.

Positive regulation of DNA repair by GRK3 expression — BREAST

Explore this box plot interactively →