GRK3

Across TCGA cell cohorts, GRK3 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible GRK3-associated genes across cancer lineages are OR11H1, KIF2B, and OR10K1. Each is linked with GRK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRK3-to-partner and partner-to-GRK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H1 grouped by GRK3-low versus GRK3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRK3→partner) and Y-score (partner→GRK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR11H1 →	+0.046	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	KIF2B →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	OR10K1 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	NLRP8 →	+0.034	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	NPAP1 →	+0.064	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	PRAMEF19 →	+0.015	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OR11H1 by GRK3 expression — BLOOD_Lymphoma

Explore this box plot interactively →