GRIP1

Across TCGA patient cohorts, GRIP1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIP1-associated genes across cancer lineages are ATM, Cyclin-B1, and FoxM1. Each is linked with GRIP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIP1-to-partner and partner-to-GRIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GRIP1-low versus GRIP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIP1→partner) and Y-score (partner→GRIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.510	-2.074	<.001	.004	3	3
UCEC	Cyclin-B1 →	+0.624	+1.947	<.001	<.001	3	3
STAD	FoxM1 →	+0.401	+2.838	.001	.033	3	2
STAD	Cyclin-E2 →	+0.147	+2.190	.021	.033	3	2
UCEC	eIF4E →	+0.152	+3.335	.018	.005	3	2
UCEC	MEK1 →	+0.478	+1.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

ATM by GRIP1 expression — UCEC

Explore this box plot interactively →