GRIP1

Across TCGA pan-cancer cohorts, GRIP1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GRIP1 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher GRIP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRIP1 expression acts as an unfavorable survival marker, although some lineages such as LGG and LIHC show a favorable association.

MESO, UVM, and LGG are the cancer types where GRIP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Tertile	III,IV	0.296	0.478	.005	45	view →
UVM	DFS	Quartile	All	0.337	0.875	.001	43	view →
LGG	DFS	Median	All	0.802	0.668	<.001	42	view →
LUAD	DFS	Median	All	0.262	0.446	.005	42	view →
LUSC	DFS	Median	III,IV	0.485	0.940	.004	37	view →
THCA	OS	Median	II,III,IV	0.561	1.000	.005	33	view →
OV	OS	Median	II,III,IV	0.659	0.725	.013	24	view →
LIHC	DFS	Quartile	III,IV	0.545	0.178	.004	23	view →
ACC	DFS	Quartile	All	0.856	0.386	.007	19	view →
BLCA	OS	Tertile	III,IV	0.458	0.203	.005	14	view →
BRCA	OS	Median	All	0.493	0.667	.004	11	view →
ESCA	OS	Tertile	All	1.000	0.535	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GRIP1–MESO (DFS)

Open the MESO breakdown →