GRIP1

Across TCGA pan-cancer cohorts, GRIP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GRIP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GRIP1 RNA is repressed in tumor relative to normal tissue. In most cancer types GRIP1 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where GRIP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRIP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	−1.005	<.001	11	view →
THCA	Male	III,IV	−1.350	<.001	10	view →
LUAD	Male	II,III,IV	+1.113	<.001	9	view →
BRCA	All	II,III,IV	+0.717	<.001	6	view →
LUSC	Male	All	+1.470	<.001	5	view →
READ	All	All	−0.908	<.001	5	view →
COAD	All	II,III,IV	−0.320	.011	5	view →
KIRP	All	II,III,IV	+0.695	.006	4	view →
UCEC	All	All	+0.659	.022	4	view →
HNSC	All	All	+0.556	.002	4	view →
CHOL	All	All	+1.426	<.001	3	view →
PRAD	All	All	−0.366	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GRIP1–KIRC

Open the KIRC breakdown →