GRIP1

Across TCGA cell cohorts, GRIP1 mutation is significantly associated with the mutation status of many other genes, with 2,550 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIP1-associated genes across cancer lineages are DOT1L, ZNF516, and KCNT2. Each is linked with GRIP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both GRIP1-to-partner and partner-to-GRIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DOT1L grouped by GRIP1-low versus GRIP1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIP1→partner) and Y-score (partner→GRIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	DOT1L →	+3.651	+4.777	.002	.002	1	5
BLOOD_Lymphoma	ZNF516 →	+4.662	+5.731	<.001	<.001	1	5
CNS	KCNT2 →	+5.044	+5.614	.003	.003	1	4
CNS	RBM12 →	+4.044	+5.000	.008	.008	1	4
BLOOD_Lymphoma	SLIT3 →	+3.440	+5.016	<.001	<.001	1	4
SKIN	SPTBN4 →	+2.772	+3.662	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,550 associations by consensus.

DOT1L by GRIP1 expression — SOFT_TISSUE

Explore this box plot interactively →