GRIN2C

Across TCGA patient cohorts, GRIN2C mutation is significantly associated with the RNA expression of many other genes, with 4,761 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN2C-associated genes across cancer lineages are SKA2, CDCA2, and PARPBP. Each is linked with GRIN2C in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIN2C-to-partner and partner-to-GRIN2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA2 grouped by GRIN2C-low versus GRIN2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2C→partner) and Y-score (partner→GRIN2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA2 →	+0.552	+2.273	.001	<.001	3	3
SKCM	CDCA2 →	+0.925	+3.334	<.001	.005	3	3
UCEC	PARPBP →	+0.542	+2.643	.001	<.001	3	3
UCEC	WDHD1 →	+0.731	+1.960	<.001	<.001	3	3
UCEC	PRC1 →	+0.817	+4.119	<.001	<.001	3	3
UCEC	C1orf174 →	+0.497	+2.273	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,761 associations by consensus.

SKA2 by GRIN2C expression — UCEC

Explore this box plot interactively →