GRIN2C

Across TCGA pan-cancer cohorts, GRIN2C RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of GRIN2C’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where GRIN2C RNA is repressed in tumor relative to normal tissue. In most cancer types GRIN2C is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where GRIN2C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRIN2C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−4.715	<.001	11	view →
LIHC	Male	All	+0.176	<.001	9	view →
COAD	All	All	+0.344	.011	4	view →
READ	Male	All	−0.190	.010	4	view →
BRCA	All	II,III,IV	+0.182	.015	4	view →
CHOL	All	All	+0.244	.002	3	view →
KIRC	All	All	+0.138	.022	2	view →
HNSC	All	IV	+0.132	.019	2	view →
BLCA	Male	IV	−0.300	.022	1	view →
LUSC	Female	II,III,IV	−0.182	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

GRIN2C–THCA

Open the THCA breakdown →