GRIN2C

Across TCGA pan-cancer cohorts, GRIN2C RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated GRIN2C data layer compared with 9 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher GRIN2C RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated GRIN2C expression acts as an unfavorable survival marker, although some lineages such as SCLC and LGG show a favorable association.

ACC, SCLC, and KIRP are the cancer types where GRIN2C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.431	0.724	<.001	81	view →
SCLC	DFS	Tertile	All	0.506	0.118	.001	70	view →
KIRP	DFS	Quartile	II,III,IV	0.247	0.892	.001	65	view →
COAD	DFS	Quartile	II,III,IV	0.564	0.778	<.001	46	view →
LGG	OS	Median	All	0.867	0.754	<.001	46	view →
UCEC	OS	Quartile	All	0.818	0.936	<.001	42	view →
PAAD	OS	Quartile	All	0.693	0.333	.017	25	view →
KIRC	DFS	Median	II,III,IV	0.424	0.620	<.001	24	view →
HNSC	DFS	Median	IV	0.718	0.570	.004	23	view →
PRAD	DFS	Tertile	All	0.815	0.933	<.001	14	view →
OV	OS	Median	III,IV	0.804	0.863	.006	12	view →
LAML	DFS	Median	All	0.355	0.558	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GRIN2C–ACC (DFS)

Open the ACC breakdown →