GRIN2C

Across TCGA patient cohorts, GRIN2C mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN2C-associated genes across cancer lineages are MEK1, 4E-BP1, and ASNS. Each is linked with GRIN2C in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIN2C-to-partner and partner-to-GRIN2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by GRIN2C-low versus GRIN2C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2C→partner) and Y-score (partner→GRIN2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.403	+2.000	.001	.003	3	3
UCEC	4E-BP1 →	+0.278	+2.252	.003	.005	3	3
COAD	ASNS →	+0.515	+3.000	.008	.035	3	3
UCEC	EGFR_pY1068 →	-0.287	-2.807	.001	.002	3	2
UCEC	JNK2 →	+0.286	+2.331	<.001	.003	3	2
UCEC	PCNA →	+0.223	+3.087	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

MEK1 by GRIN2C expression — UCEC

Explore this box plot interactively →