GRIN2C

Across TCGA cell cohorts, GRIN2C mutation is significantly associated with the RNA expression of many other genes, with 1,083 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIN2C-associated genes across cancer lineages are POTEB3, AGTR2, and TFAP2E. Each is linked with GRIN2C in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIN2C-to-partner and partner-to-GRIN2C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEB3 grouped by GRIN2C-low versus GRIN2C-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2C→partner) and Y-score (partner→GRIN2C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	POTEB3 →	+0.028	+3.432	<.001	.008	3	2
LUNG_SCLC	AGTR2 →	+0.032	+4.256	<.001	.002	3	2
LARGE_INTESTINE	TFAP2E →	+0.909	+2.386	<.001	.007	3	2
LARGE_INTESTINE	SNX22 →	+0.479	+2.700	<.001	.001	3	2
LARGE_INTESTINE	RFX7 →	+0.602	+3.169	.002	.009	3	2
CNS	C11orf97 →	+0.043	+4.832	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,083 associations by consensus.

POTEB3 by GRIN2C expression — STOMACH

Explore this box plot interactively →