GRIN2B

Across TCGA patient cohorts, GRIN2B mutation is significantly associated with the RNA expression of many other genes, with 5,158 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIN2B-associated genes across cancer lineages are ZNF367, PSMC3IP, and TMEM269. Each is linked with GRIN2B in more than 4 cancer types. Because this analysis shows association rather than direction, both GRIN2B-to-partner and partner-to-GRIN2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by GRIN2B-low versus GRIN2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2B→partner) and Y-score (partner→GRIN2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.548	+1.584	<.001	<.001	3	5
UCEC	PSMC3IP →	+0.468	+1.461	<.001	<.001	3	5
UCEC	TMEM269 →	+0.116	+1.110	<.001	.004	3	5
SKCM	PPIP5K1 →	+0.225	+0.799	.005	.007	3	4
UCEC	MTA2 →	+0.287	+1.820	<.001	<.001	3	4
COAD	SKA1 →	+0.674	+2.335	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,158 associations by consensus.

ZNF367 by GRIN2B expression — UCEC

Explore this box plot interactively →