GRIN2B

Across TCGA pan-cancer cohorts, GRIN2B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GRIN2B data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher GRIN2B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GRIN2B expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

KICH, UCS, and LUAD are the cancer types where GRIN2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.725	0.979	<.001	95	view →
UCS	OS	Quartile	II,III,IV	0.828	0.160	<.001	84	view →
LUAD	OS	Tertile	II,III,IV	0.512	0.725	<.001	84	view →
UVM	DFS	Tertile	All	0.585	0.894	.004	75	view →
UCEC	DFS	Median	All	0.791	0.882	.001	52	view →
SCLC	OS	Tertile	All	0.581	0.233	.003	34	view →
CESC	DFS	Tertile	All	0.639	0.782	.006	28	view →
LGG	OS	Median	All	0.941	0.834	<.001	25	view →
ESCA	OS	Quartile	III,IV	0.614	0.269	.009	24	view →
KIRP	DFS	Quartile	All	0.819	0.944	.003	23	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	21	view →
LIHC	DFS	Median	All	0.540	0.361	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GRIN2B–KICH (OS)

Open the KICH breakdown →