GRIN2B

Across TCGA pan-cancer cohorts, GRIN2B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of GRIN2B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GRIN2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types GRIN2B is over-expressed in tumor, although a few such as LIHC and THCA show the opposite, repressed pattern.

COAD, LIHC, and THCA are the cancer types where GRIN2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRIN2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	+0.590	<.001	10	view →
LIHC	Female	All	−0.207	<.001	8	view →
THCA	Female	All	−0.015	<.001	7	view →
BRCA	All	III,IV	−0.448	<.001	6	view →
STAD	All	All	+0.129	.002	6	view →
READ	All	All	+0.831	.011	2	view →
KIRP	All	II,III,IV	+0.193	.015	2	view →
CHOL	Female	All	−0.303	.009	1	view →
KIRC	Female	IV	−0.084	.002	1	view →
KICH	Female	II,III,IV	−0.067	.005	1	view →
LUAD	Female	II,III,IV	−0.012	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

GRIN2B–COAD

Open the COAD breakdown →