GRIN2B

Across TCGA cell cohorts, GRIN2B mutation is significantly associated with the RNA expression of many other genes, with 1,821 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIN2B-associated genes across cancer lineages are MRAP, KCNAB3, and C20orf173. Each is linked with GRIN2B in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIN2B-to-partner and partner-to-GRIN2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRAP grouped by GRIN2B-low versus GRIN2B-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2B→partner) and Y-score (partner→GRIN2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	MRAP →	+0.024	+3.209	<.001	.007	3	3
LARGE_INTESTINE	KCNAB3 →	+0.586	+1.949	.002	.002	3	3
LUNG_SCLC	C20orf173 →	+0.042	+3.247	<.001	<.001	3	2
LUNG_NSCLC_LUSC	ATOH7 →	+0.221	+3.125	<.001	.008	2	3
CNS	OR4D2 →	+0.012	+4.772	<.001	.002	3	2
LARGE_INTESTINE	EIF3L →	+0.455	+2.526	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,821 associations by consensus.

MRAP by GRIN2B expression — STOMACH

Explore this box plot interactively →