Across TCGA cell cohorts, GRIN2A mutation is significantly associated with the RNA expression of many other genes, with 629 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIN2A-associated genes across cancer lineages are RCHY1, GCK, and CYP4B1. Each is linked with GRIN2A in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIN2A-to-partner and partner-to-GRIN2A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIN2A→partner) and Y-score (partner→GRIN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RCHY1 →	+0.672	+2.364	.001	<.001	3	2
BLOOD_Leukemia	GCK →	+0.175	+3.888	.004	<.001	3	2
BLOOD_Lymphoma	CYP4B1 →	+0.375	+2.589	<.001	.003	3	2
SKIN	EXOSC9 →	+0.441	+3.321	.002	.002	3	2
SKIN	CKS1B →	+0.517	+3.169	.007	.006	3	2
LARGE_INTESTINE	HASPIN →	+0.516	+1.850	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 629 associations by consensus.

Exploration

GRIN2A survival (RNA) · tumor vs normal (RNA) · all GRIN2A data types