GRIK4

Across TCGA cell cohorts, GRIK4 mutation is significantly associated with the RNA expression of many other genes, with 538 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIK4-associated genes across cancer lineages are FAM153CP, KRTAP5-3, and HMGXB4. Each is linked with GRIK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRIK4-to-partner and partner-to-GRIK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM153CP grouped by GRIK4-low versus GRIK4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK4→partner) and Y-score (partner→GRIK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM153CP →	+0.214	+2.438	<.001	<.001	3	3
PANCREAS	KRTAP5-3 →	+0.035	+5.000	<.001	.006	3	2
LARGE_INTESTINE	HMGXB4 →	+0.488	+3.339	.003	.001	3	2
LARGE_INTESTINE	CCP110 →	+0.691	+3.252	<.001	.002	3	2
LARGE_INTESTINE	FAM149A →	+1.161	+3.252	<.001	.002	3	2
LARGE_INTESTINE	BCL7A →	+0.701	+3.169	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 538 associations by consensus.

FAM153CP by GRIK4 expression — LARGE_INTESTINE

Explore this box plot interactively →