GRIK4

Across TCGA pan-cancer cohorts, GRIK4 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated GRIK4 data layer compared with 11 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GRIK4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GRIK4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and HNSC show a favorable association.

BRCA, KIRP, and HNSC are the cancer types where GRIK4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	IV	0.849	0.293	<.001	82	view →
KIRP	OS	Median	All	0.458	0.814	<.001	63	view →
HNSC	DFS	Median	II,III,IV	0.410	0.247	.003	55	view →
KIRC	OS	Median	All	0.563	0.693	<.001	48	view →
LGG	OS	Median	All	0.528	0.367	<.001	45	view →
SKCM	OS	Tertile	IV	0.896	0.411	<.001	42	view →
ACC	DFS	Tertile	III,IV	0.515	0.062	.004	38	view →
UVM	DFS	Tertile	III,IV	0.157	1.000	.007	23	view →
UCS	DFS	Median	III,IV	0.508	0.165	.014	18	view →
THCA	DFS	Median	All	0.879	0.775	<.001	17	view →
ESCA	OS	Median	II,III,IV	0.618	0.406	.012	15	view →
OV	DFS	Quartile	IV	0.503	0.232	.021	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GRIK4–BRCA (OS)

Open the BRCA breakdown →