GRIK2

Across TCGA patient cohorts, GRIK2 mutation is significantly associated with the RNA expression of many other genes, with 5,496 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIK2-associated genes across cancer lineages are CENPM, MRPS5, and MIS18A. Each is linked with GRIK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both GRIK2-to-partner and partner-to-GRIK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by GRIK2-low versus GRIK2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK2→partner) and Y-score (partner→GRIK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CENPM →	+0.675	+2.378	<.001	<.001	3	7
LUAD	MRPS5 →	+0.236	+1.865	.003	.004	3	6
LUAD	MIS18A →	+0.513	+2.082	<.001	<.001	3	6
LUAD	CHAF1B →	+0.529	+2.058	<.001	<.001	3	6
LUAD	SNRPD1 →	+0.478	+2.099	<.001	.002	3	6
HNSC	PAXX →	+0.871	+3.192	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,496 associations by consensus.

CENPM by GRIK2 expression — LUAD

Explore this box plot interactively →