GRIK2

Across TCGA pan-cancer cohorts, GRIK2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated GRIK2 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher GRIK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GRIK2 expression acts as an unfavorable survival marker, although some lineages such as LGG and ACC show a favorable association.

STAD, LUAD, and BLCA are the cancer types where GRIK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	All	0.479	0.666	.003	45	view →
LUAD	DFS	Tertile	All	0.527	0.749	.001	45	view →
BLCA	DFS	Quartile	II,III,IV	0.514	0.676	.004	44	view →
LGG	DFS	Median	All	0.815	0.657	<.001	42	view →
SKCM	DFS	Median	II,III,IV	0.469	0.687	.001	37	view →
COAD	DFS	Tertile	All	0.725	0.830	.002	27	view →
ACC	DFS	Median	All	0.800	0.452	.004	19	view →
DLBC	OS	Median	II,III,IV	0.714	1.000	.005	16	view →
BRCA	OS	Tertile	II,III,IV	0.478	0.634	.026	14	view →
KIRC	OS	Median	II,III,IV	0.445	0.599	.019	13	view →
THYM	OS	Median	II,III,IV	0.882	1.000	.008	12	view →
CESC	DFS	Tertile	All	0.396	0.668	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GRIK2–STAD (OS)

Open the STAD breakdown →