GRIK2

Across TCGA pan-cancer cohorts, GRIK2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of GRIK2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where GRIK2 RNA is repressed in tumor relative to normal tissue. In most cancer types GRIK2 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where GRIK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRIK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.010	<.001	12	view →
KIRP	Male	All	−0.753	<.001	11	view →
KICH	Male	II,III,IV	−1.067	<.001	10	view →
LUAD	Male	II,III,IV	+0.976	<.001	9	view →
THCA	Male	III,IV	−1.420	<.001	7	view →
COAD	All	II,III,IV	−0.306	<.001	7	view →
UCEC	All	All	+0.781	.003	4	view →
LUSC	All	All	+0.376	<.001	4	view →
STAD	All	All	−0.451	.004	3	view →
BRCA	All	II,III,IV	+0.135	.016	3	view →
READ	All	All	−0.592	.001	2	view →
ESCA	All	All	−0.448	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

GRIK2–KIRC

Open the KIRC breakdown →