GRIK2

Across TCGA cell cohorts, GRIK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,390 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GRIK2-associated GO terms across cancer lineages are Endosomal transport, Nuclear envelope organization, and Negative regulation of synaptic transmission, glutamatergic. Each is linked with GRIK2 in more than 7 cancer types. Because this analysis shows association rather than direction, both GRIK2-to-partner and partner-to-GRIK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by GRIK2-low versus GRIK2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK2→partner) and Y-score (partner→GRIK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.056	+0.467	<.001	.003	3	8
BLOOD_Leukemia	Nuclear envelope organization →	+0.034	+0.140	<.001	.005	3	8
OESOPHAGUS	Negative regulation of synaptic transmission, glutamatergic →	-0.402	-1.201	<.001	.002	3	8
LIVER	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.090	+1.077	.006	.005	3	8
OESOPHAGUS	Transcription elongation by RNA polymerase II →	+0.102	+1.160	.004	.004	3	8
SKIN	Potassium ion transport →	-0.044	-1.741	.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,390 associations by consensus.

Endosomal transport by GRIK2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →