GRIK2

Across TCGA cell cohorts, GRIK2 mutation is significantly associated with the RNA expression of many other genes, with 1,546 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIK2-associated genes across cancer lineages are TRIM62, CTC1, and C12orf40. Each is linked with GRIK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIK2-to-partner and partner-to-GRIK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM62 grouped by GRIK2-low versus GRIK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIK2→partner) and Y-score (partner→GRIK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRIM62 →	+0.524	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	CTC1 →	+0.989	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	C12orf40 →	+0.004	+1.836	.001	.009	3	2
LARGE_INTESTINE	NLRP2 →	+1.539	+2.617	.009	.002	3	2
LARGE_INTESTINE	FDXACB1 →	+0.529	+3.459	<.001	.001	3	2
LARGE_INTESTINE	MACROH2A2 →	+1.569	+1.941	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,546 associations by consensus.

TRIM62 by GRIK2 expression — LARGE_INTESTINE

Explore this box plot interactively →