GRIA4

Across TCGA patient cohorts, GRIA4 mutation is significantly associated with the RNA expression of many other genes, with 7,083 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRIA4-associated genes across cancer lineages are SUV39H2, POLE2, and CENPA. Each is linked with GRIA4 in more than 5 cancer types. Because this analysis shows association rather than direction, both GRIA4-to-partner and partner-to-GRIA4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUV39H2 grouped by GRIA4-low versus GRIA4-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA4→partner) and Y-score (partner→GRIA4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SUV39H2 →	+0.522	+3.182	.002	.009	3	6
LUAD	POLE2 →	+0.728	+3.471	<.001	.002	3	5
LUAD	CENPA →	+0.909	+2.426	.001	.002	3	5
UCEC	MND1 →	+0.638	+1.777	<.001	<.001	3	5
LUAD	HROB →	+0.621	+2.426	.007	.002	3	5
STAD	TRAIP →	+0.587	+2.733	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,083 associations by consensus.

SUV39H2 by GRIA4 expression — STAD

Explore this box plot interactively →