GRIA4

Across TCGA pan-cancer cohorts, GRIA4 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of GRIA4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where GRIA4 RNA is repressed in tumor relative to normal tissue. In most cancer types GRIA4 is over-expressed in tumor, although a few such as COAD and STAD show the opposite, repressed pattern.

COAD, KIRC, and STAD are the cancer types where GRIA4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in GRIA4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.453	<.001	11	view →
KIRC	All	All	+1.254	<.001	10	view →
STAD	Male	IV	−0.790	<.001	9	view →
THCA	Male	All	−0.082	<.001	8	view →
KICH	All	All	−0.247	<.001	7	view →
BRCA	All	III,IV	−1.885	<.001	6	view →
READ	All	All	−0.525	<.001	5	view →
UCEC	All	All	−0.326	.005	4	view →
HNSC	All	II,III,IV	−0.115	.003	4	view →
LUAD	All	All	+0.126	.003	3	view →
PRAD	All	All	−0.056	.011	2	view →
CHOL	All	All	+0.054	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

GRIA4–COAD

Open the COAD breakdown →